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KMID : 0191120160310020315
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Journal of Korean Medical Science
2016 Volume.31 No. 2 p.315 ~ p.320
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Isolation of Middle East Respiratory Syndrome Coronavirus from a Patient of the 2015 Korean Outbreak
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Park Wan-Beom
Kwon Nak-Jung
Choe Pyoeng-Gyun
Choi Su-Jin
Oh Hong-Sang
Lee Sang-Min
Chong Hyon-yong
Kim Jong-Il
Song Kyoung-Ho
Bang Ji-Hwan
Kim Eu-Suk
Kim Hong-Bin
Park Sang-Won
Kim Nam-Joong
Oh Myoung-Don
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Abstract
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During the 2015 outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) in Korea, 186 persons were infected, resulting in 38 fatalities. We isolated MERS-CoV from the oropharyngeal sample obtained from a patient of the outbreak. Cytopathic effects showing detachment and rounding of cells were observed in Vero cell cultures 3 days after inoculation of the sample. Spherical virus particles were observed by transmission electron microscopy. Full-length genome sequence of the virus isolate was obtained and phylogenetic analyses showed that it clustered with clade B of MERS-CoV.
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KEYWORD
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Middle East Respiratory Syndrome, Middle East Respiratory Syndrome Coronavirus, Microscopy, Electron, Phylogeny, Korea
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